DNA Damage; Gene Expression Regulation/genetics; Intracellular Signaling Peptides and Proteins/genetics; Tumor Suppressor Protein p53/genetics; Animals; Antibiotics, Antineoplastic/pharmacology; Base Sequence; Binding Sites/genetics; Blotting, Western; Cell Line, Tumor; Cells, Cultured; DNA-Binding Proteins; Doxorubicin/pharmacology; Embryo, Mammalian/cytology; Fibroblasts/cytology; Fibroblasts/drug effects; Fibroblasts/metabolism; Gene Expression Regulation/drug effects; HCT116 Cells; HEK293 Cells; Humans; Mice; Mice, Transgenic; Molecular Sequence Data; Mutation; Promoter Regions, Genetic/genetics; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; Sequence Homology, Nucleic Acid; Transcription Factors; Tumor Suppressor Protein p53/metabolism