Aorta/metabolism; Atherosclerosis/genetics; Brachiocephalic Trunk/metabolism; Plaque, Atherosclerotic/genetics; RANK Ligand/genetics; TNF-Related Apoptosis-Inducing Ligand/genetics; Vascular Calcification/genetics; Animals; Aorta/pathology; Apolipoproteins E/deficiency; Apolipoproteins E/genetics; Atherosclerosis/metabolism; Atherosclerosis/pathology; Brachiocephalic Trunk/pathology; Calcium/metabolism; Calcium/pharmacology; Cells, Cultured; Chondrocytes/drug effects; Chondrocytes/metabolism; Chondrocytes/pathology; Collagen Type II/genetics; Collagen Type II/metabolism; Diet, High-Fat; Gene Expression Regulation; Humans; Mice; Mice, Knockout; Muscle, Smooth, Vascular/drug effects; Muscle, Smooth, Vascular/metabolism; Muscle, Smooth, Vascular/pathology; Myocytes, Smooth Muscle/drug effects; Myocytes, Smooth Muscle/metabolism; Myocytes, Smooth Muscle/pathology; Osteoprotegerin/genetics; Osteoprotegerin/metabolism; Plaque, Atherosclerotic/metabolism; Plaque, Atherosclerotic/pathology; RANK Ligand/metabolism; RNA, Messenger/genetics; RNA, Messenger/metabolism; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand/deficiency; TNF-Related Apoptosis-Inducing Ligand/pharmacology; Vascular Calcification/metabolism; Vascular Calcification/pathology