Design and evaluation of novel 8-oxo-pyridopyrimidine Jak1/2 inhibitors.

Labadie, Sharada; Barrett, Kathy; Blair, Wade S; Chang, Christine; Deshmukh, Gauri; Eigenbrot, Charles; Gibbons, Paul; Johnson, Adam; Kenny, Jane R; Kohli, Pawan Bir; Liimatta, Marya; Lupardus, Patrick J; Shia, Steven; Steffek, Micah; Ubhayakar, Savita; van Abbema, Anne; Zak, Mark

Labadie, Sharada; Barrett, Kathy; Blair, Wade S; Chang, Christine; Deshmukh, Gauri; Eigenbrot, Charles; Gibbons, Paul; Johnson, Adam; Kenny, Jane R; Kohli, Pawan Bir; Liimatta, Marya; Lupardus, Patrick J; Shia, Steven; Steffek, Micah; Ubhayakar, Savita; van Abbema, Anne; Zak, Mark.

Affiliation

Labadie S; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address: sharadal@gene.com.

Bioorg Med Chem Lett ; 23(21): 5923-30, 2013 Nov 01.

Article in En | MEDLINE | ID: mdl-24042009

Subject(s)

Janus Kinase 1/antagonists & inhibitors; Janus Kinase 2/antagonists & inhibitors; Protein Kinase Inhibitors/chemistry; Protein Kinase Inhibitors/pharmacology; Pyrimidines/chemistry; Pyrimidines/pharmacology; Humans; Janus Kinase 1/chemistry; Janus Kinase 1/metabolism; Janus Kinase 2/chemistry; Janus Kinase 2/metabolism; Molecular Docking Simulation; Structure-Activity Relationship

Key words

8-Oxo-pyridopyrimidines; Hematopoiesis; JAK inhibitors; Rheumatoid arthritis

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Protein Kinase Inhibitors / Janus Kinase 1 / Janus Kinase 2 Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2013 Document type: Article Country of publication: United kingdom

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google