A novel transgenic mouse model of growth plate dysplasia reveals that decreased chondrocyte proliferation due to chronic ER stress is a key factor in reduced bone growth.

Gualeni, Benedetta; Rajpar, M Helen; Kellogg, Aaron; Bell, Peter A; Arvan, Peter; Boot-Handford, Raymond P; Briggs, Michael D

Gualeni, Benedetta; Rajpar, M Helen; Kellogg, Aaron; Bell, Peter A; Arvan, Peter; Boot-Handford, Raymond P; Briggs, Michael D.

Affiliation

Gualeni B; Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, M13 9PT, UK.

Dis Model Mech ; 6(6): 1414-25, 2013 Nov.

Article in En | MEDLINE | ID: mdl-24046357

Subject(s)

Bone Development; Cell Proliferation; Chondrocytes/pathology; Endoplasmic Reticulum/metabolism; Growth Plate/pathology; Animals; Apoptosis; Mice; Mice, Transgenic; Transcription, Genetic

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bone Development / Chondrocytes / Cell Proliferation / Endoplasmic Reticulum / Growth Plate Type of study: Prognostic_studies Limits: Animals Language: En Journal: Dis Model Mech Journal subject: MEDICINA Year: 2013 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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