Substrate-mediated proton relay mechanism for the religation reaction in topoisomerase II.

Hanaoka, Kyohei; Shoji, Mitsuo; Kondo, Daiki; Sato, Akimasa; Yang, Moon Young; Kamiya, Katsumasa; Shiraishi, Kenji

Hanaoka, Kyohei; Shoji, Mitsuo; Kondo, Daiki; Sato, Akimasa; Yang, Moon Young; Kamiya, Katsumasa; Shiraishi, Kenji.

Affiliation

Hanaoka K; a Graduate School of Pure and Applied Sciences, University of Tsukuba , Tennodai 1-1-1, Tsukuba , 305-8571 , Japan .

J Biomol Struct Dyn ; 32(11): 1759-65, 2014.

Article in En | MEDLINE | ID: mdl-24047515

Subject(s)

DNA Topoisomerases, Type II/chemistry; Protons; Saccharomyces cerevisiae Proteins/chemistry; Arginine/chemistry; Biocatalysis; Hydroxyl Radical/chemistry; Models, Molecular; Quantum Theory; Substrate Specificity; Tyrosine/chemistry

Key words

DNA religation; QM/MM study; catalytic mechanism; proton transfer; topoisomerase II

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protons / DNA Topoisomerases, Type II / Saccharomyces cerevisiae Proteins Language: En Journal: J Biomol Struct Dyn Year: 2014 Document type: Article Affiliation country: Japan Country of publication: United kingdom

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