The role of ECL2 in CGRP receptor activation: a combined modelling and experimental approach.

Woolley, Michael J; Watkins, Harriet A; Taddese, Bruck; Karakullukcu, Z Gamze; Barwell, James; Smith, Kevin J; Hay, Debbie L; Poyner, David R; Reynolds, Christopher A; Conner, Alex C

Woolley, Michael J; Watkins, Harriet A; Taddese, Bruck; Karakullukcu, Z Gamze; Barwell, James; Smith, Kevin J; Hay, Debbie L; Poyner, David R; Reynolds, Christopher A; Conner, Alex C.

Affiliation

Woolley MJ; Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK.

J R Soc Interface ; 10(88): 20130589, 2013 Nov 06.

Article in En | MEDLINE | ID: mdl-24047872

Subject(s)

Calcitonin Receptor-Like Protein/metabolism; Models, Molecular; Receptors, Calcitonin Gene-Related Peptide/metabolism; Adrenomedullin/chemistry; Adrenomedullin/immunology; Adrenomedullin/metabolism; Animals; COS Cells; Calcitonin Receptor-Like Protein/chemistry; Calcitonin Receptor-Like Protein/genetics; Cyclic AMP/metabolism; Humans; Protein Structure, Secondary; Protein Structure, Tertiary; Receptors, Calcitonin Gene-Related Peptide/chemistry; Receptors, Calcitonin Gene-Related Peptide/genetics

Key words

calcitonin gene-related peptide; calcitonin receptor-like receptor; class B G-protein-coupled receptor; loop modelling; site-directed mutagenesis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Models, Molecular / Receptors, Calcitonin Gene-Related Peptide / Calcitonin Receptor-Like Protein Limits: Animals / Humans Language: En Journal: J R Soc Interface Year: 2013 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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