Circulating vascular endothelial growth factor concentrations in patients with postmenopausal osteoporosis.
Arch Med Sci
; 9(4): 709-12, 2013 Aug 30.
Article
in En
| MEDLINE
| ID: mdl-24049533
ABSTRACT
INTRODUCTION:
The role of vascular endothelial growth factor (VEGF) in osteoporosis has not yet been clearly established. Vascular endothelial growth factor is an important part of bone formation. In the literature, although the effects of VEGF on bone metabolism were investigated by different studies, there are very rare studies analysing the association between osteoporosis and VEGF. In the present study, our objective was to investigate serum VEGF concentrations in patients with postmenopausal osteoporosis (PMO) and the correlation of serum VEGF levels and bone mineral density (BMD). MATERIAL ANDMETHODS:
This study was performed on 35 PMO patients, and 30 age-matched healthy controls. Serum VEGF concentrations were measured using a quantitative sandwich enzyme immunoassay technique according to the manufacturer's instructions. Bone mineral density values were determined by dual energy X-ray absorptiometry (DEXA).RESULTS:
Serum VEGF concentrations were statistically significantly lower in PMO patients than in controls (150 ±65 pg/ml, 260 ±135 pg/ml respectively; p = 0.005). A positive correlation was found between serum VEGF concentrations and BMD values (r = 0.63, p = 0.001).CONCLUSIONS:
Vascular endothelial growth factor concentrations were decreased in PMO patients and VEGF may play an important role in bone health.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Arch Med Sci
Year:
2013
Document type:
Article
Affiliation country:
Turkey