Cannabis; Diet; Multiple Sclerosis/drug therapy; Oenothera biennis; Phytotherapy/methods; Plant Extracts/administration & dosage; Plant Oils/administration & dosage; Adult; Cytokines/blood; Double-Blind Method; Fatty Acids, Unsaturated/metabolism; Female; Humans; Inflammation; Iran; Male; Medicine, Traditional; Metabolic Networks and Pathways; Multiple Sclerosis/blood; Multiple Sclerosis/diet therapy; Multiple Sclerosis/immunology; Seeds

(FADS2)delta-6-desaturase; (STA) stearidonic acid; AA; ALA; CMF; CNS; D6D; DGLA; DHA; EDSS; EFAs; EP; EPA; EPO; Evening primrose (Oenothera biennis L.); Expanded Disability Status Scale; FAME; FAs; FDA; FR; GC; GLA; HS; HSO; Hemp seed (Cannabis sativa L.); Hot-nature diet; IFN; IFN-γ; IL; Inflammation; LA; LC-PUFA; MS; MUFA; Mizadj; Multiple sclerosis; NSRC; Neurosciences Research Center; PGE; PUFA; RBCs; RRMS; SDA; SFAs; T helper (1-2); TIM; Th; Traditional Iranian Medicine; USFA; W/C; Warmth/Coldness; alpha-linolenic acid; arachidonic acid; cell membrane fluidity; central nervous system; dihomo-gamma-linolenic acid; docosahexanoic acid (key omega-3); eicosapentaenoic acid; essential fatty acids; evening primrose; evening primrose oil; fatty acid methyl esters; fatty acids; food and drug administration; food records; gamma linolenic acid; gas chromatography; hemp seed; hemp seed oil; interferon (ß1b-ß1a-ß); interferon-γ; interleukin-4; linoleic acid (omega-6 family); long chain-polyunsaturated fatty acid; monounsaturated fatty acids; multiple sclerosis; non-quantitative Food Frequency Questionnaires; nqFFQ; omega-3polyunsaturated fatty acids; polyunsaturated fatty acid; prostaglandin (E1, E2, E3); red blood cells; relapsing remitting multiple sclerosis; saturated fatty acids; unsaturated fatty acid; ω3-PUFAs