Zebularine induces chemosensitization to methotrexate and efficiently decreases AhR gene methylation in childhood acute lymphoblastic leukemia cells.

Andrade, Augusto F; Borges, Kleiton S; Castro-Gamero, Angel M; Silveira, Vanessa S; Suazo, Veridiana K; Oliveira, Jaqueline C; Moreno, Daniel A; de Paula Queiroz, Rosane G; Scrideli, Carlos A; Tone, Luiz G

Andrade, Augusto F; Borges, Kleiton S; Castro-Gamero, Angel M; Silveira, Vanessa S; Suazo, Veridiana K; Oliveira, Jaqueline C; Moreno, Daniel A; de Paula Queiroz, Rosane G; Scrideli, Carlos A; Tone, Luiz G.

Affiliation

Andrade AF; Departments of aGenetics bPediatrics, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, SP, Brazil.

Anticancer Drugs ; 25(1): 72-81, 2014 Jan.

Article in En | MEDLINE | ID: mdl-24052107

Subject(s)

Antineoplastic Agents/pharmacology; Basic Helix-Loop-Helix Transcription Factors/metabolism; Cytidine/analogs & derivatives; DNA Modification Methylases/antagonists & inhibitors; Methotrexate/pharmacology; Precursor Cell Lymphoblastic Leukemia-Lymphoma/metabolism; Receptors, Aryl Hydrocarbon/metabolism; Apoptosis/drug effects; Basic Helix-Loop-Helix Transcription Factors/genetics; Cell Line, Tumor; Cytidine/pharmacology; Drug Antagonism; Drug Resistance, Neoplasm; Drug Synergism; Humans; Methylation; Receptors, Aryl Hydrocarbon/genetics; Vincristine/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Modification Methylases / Methotrexate / Receptors, Aryl Hydrocarbon / Cytidine / Basic Helix-Loop-Helix Transcription Factors / Precursor Cell Lymphoblastic Leukemia-Lymphoma / Antineoplastic Agents Limits: Humans Language: En Journal: Anticancer Drugs Journal subject: ANTINEOPLASICOS Year: 2014 Document type: Article Affiliation country: Brazil Country of publication: United kingdom

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