New way to substitute tetracyanocyclopropanes: one-pot cascade assembling of carbonyls and malononitrile by the only bromine direct action.
ISRN Org Chem
; 2011: 469453, 2011.
Article
in En
| MEDLINE
| ID: mdl-24052823
ABSTRACT
THE NEW TYPE OF THE CHEMICAL CASCADE REACTION WAS FOUND formation of cyclopropanes from carbonyl compounds and CH acid by the only bromine direct action. The action of aqueous bromine on the carbonyl compounds and malononitrile in EtOH-H2O solutions in the presence of NaOAc results in the formation of 3-substituted 1,1,2,2-tetracyanocyclopropanes in 48-93% yields. The latter are well-known precursors for the different bicyclic heterosystems, among them those containing cyclopropane ring and those possessing different types of pharmacological activity.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
ISRN Org Chem
Year:
2011
Document type:
Article
Affiliation country:
RUSSIA