Synthesis of amino-hydroxy-benzocycloheptenones as potent, selective, non-peptidic dinuclear zinc metalloaminopeptidase inhibitors.

Al-Lakkis-Wehbe, Mira; Chaillou, Bérénice; Defoin, Albert; Albrecht, Sébastien; Tarnus, Céline

Al-Lakkis-Wehbe, Mira; Chaillou, Bérénice; Defoin, Albert; Albrecht, Sébastien; Tarnus, Céline.

Affiliation

Al-Lakkis-Wehbe M; Université de Haute Alsace, Laboratoire de Chimie Organique et Bioorganique, EA4466, ENSCMu, 3, rue Alfred Werner, F-68093 Mulhouse Cedex, France.

Bioorg Med Chem ; 21(21): 6447-55, 2013 Nov 01.

Article in En | MEDLINE | ID: mdl-24055078

Subject(s)

Aminopeptidases/antagonists & inhibitors; Benzocycloheptenes/chemistry; Protease Inhibitors/chemical synthesis; Aeromonas/enzymology; Aminopeptidases/metabolism; Benzocycloheptenes/chemical synthesis; Benzocycloheptenes/metabolism; Binding Sites; Catalytic Domain; Escherichia coli/enzymology; Molecular Docking Simulation; Protease Inhibitors/chemistry; Protease Inhibitors/metabolism; Protein Binding; Structure-Activity Relationship; Zinc/chemistry

Key words

M1 aminopeptidases; M28 aminopeptidases; Racemic trisubstituted benzocycloheptane derivatives; Selective inhibition; Synthetic inhibitors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protease Inhibitors / Benzocycloheptenes / Aminopeptidases Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2013 Document type: Article Affiliation country: France Country of publication: United kingdom

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