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Mitochondrial glutathione depletion reveals a novel role for the pyruvate dehydrogenase complex as a key H2O2-emitting source under conditions of nutrient overload.
Fisher-Wellman, Kelsey H; Gilliam, Laura A A; Lin, Chien-Te; Cathey, Brook L; Lark, Daniel S; Darrell Neufer, P.
Affiliation
  • Fisher-Wellman KH; East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC 27858, USA; Department of Physiology, East Carolina University, Greenville, NC 27858, USA. Electronic address: k.fisher-wellman@garvan.org.au.
  • Gilliam LAA; East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC 27858, USA; Department of Physiology, East Carolina University, Greenville, NC 27858, USA.
  • Lin CT; East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC 27858, USA; Department of Physiology, East Carolina University, Greenville, NC 27858, USA.
  • Cathey BL; East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC 27858, USA; Department of Physiology, East Carolina University, Greenville, NC 27858, USA.
  • Lark DS; East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC 27858, USA; Department of Kinesiology, East Carolina University, Greenville, NC 27858, USA.
  • Darrell Neufer P; East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC 27858, USA; Department of Physiology, East Carolina University, Greenville, NC 27858, USA; Department of Kinesiology, East Carolina University, Greenville, NC 27858, USA.
Free Radic Biol Med ; 65: 1201-1208, 2013 Dec.
Article in En | MEDLINE | ID: mdl-24056031
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyruvate Dehydrogenase Complex / Superoxides / Glutathione / Hydrogen Peroxide / Mitochondria, Muscle Type of study: Prognostic_studies Limits: Adult / Animals / Female / Humans / Male Language: En Journal: Free Radic Biol Med Journal subject: BIOQUIMICA / MEDICINA Year: 2013 Document type: Article Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyruvate Dehydrogenase Complex / Superoxides / Glutathione / Hydrogen Peroxide / Mitochondria, Muscle Type of study: Prognostic_studies Limits: Adult / Animals / Female / Humans / Male Language: En Journal: Free Radic Biol Med Journal subject: BIOQUIMICA / MEDICINA Year: 2013 Document type: Article Country of publication: United States