miR128 up-regulation correlates with impaired amyloid ß(1-42) degradation in monocytes from patients with sporadic Alzheimer's disease.

Tiribuzi, Roberto; Crispoltoni, Lucia; Porcellati, Serena; Di Lullo, Martina; Florenzano, Fulvio; Pirro, Matteo; Bagaglia, Francesco; Kawarai, Toshitaka; Zampolini, Mauro; Orlacchio, Aldo; Orlacchio, Antonio

Tiribuzi, Roberto; Crispoltoni, Lucia; Porcellati, Serena; Di Lullo, Martina; Florenzano, Fulvio; Pirro, Matteo; Bagaglia, Francesco; Kawarai, Toshitaka; Zampolini, Mauro; Orlacchio, Aldo; Orlacchio, Antonio.

Affiliation

Tiribuzi R; Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università di Perugia, Perugia, Italy.

Neurobiol Aging ; 35(2): 345-56, 2014 Feb.

Article in En | MEDLINE | ID: mdl-24064186

Subject(s)

Alzheimer Disease/genetics; Alzheimer Disease/metabolism; Amyloid beta-Peptides/metabolism; MicroRNAs/metabolism; Monocytes/metabolism; Peptide Fragments/metabolism; Proteolysis; Aged; Cathepsins/metabolism; Cathepsins/physiology; Cells, Cultured; Female; Humans; Lymphocytes/enzymology; Lymphocytes/metabolism; Lysosomes/enzymology; Male; Monocytes/enzymology; Up-Regulation; alpha-Mannosidase/metabolism; alpha-Mannosidase/physiology; beta-Galactosidase/metabolism; beta-Galactosidase/physiology; beta-N-Acetylhexosaminidases/metabolism; beta-N-Acetylhexosaminidases/physiology

Key words

Cathepsin B; Lysosomal enzymes; Monocytes; Sporadic Alzheimer's disease; TFEB; miR-128

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Monocytes / Amyloid beta-Peptides / MicroRNAs / Alzheimer Disease / Proteolysis Limits: Aged / Female / Humans / Male Language: En Journal: Neurobiol Aging Year: 2014 Document type: Article Affiliation country: Italy Country of publication: United States

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