Mycoplasma hyorhinis-encoded purine nucleoside phosphorylase: kinetic properties and its effect on the cytostatic potential of purine-based anticancer drugs.

Vande Voorde, Johan; Liekens, Sandra; Balzarini, Jan

Vande Voorde, Johan; Liekens, Sandra; Balzarini, Jan.

Affiliation

Vande Voorde J; Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.

Mol Pharmacol ; 84(6): 865-75, 2013 Dec.

Article in En | MEDLINE | ID: mdl-24068428

Subject(s)

Antineoplastic Agents/pharmacology; Mycoplasma hyorhinis/enzymology; Purine-Nucleoside Phosphorylase/metabolism; Purines/pharmacology; Antineoplastic Agents/metabolism; Cell Line, Tumor; Cladribine/metabolism; Cladribine/pharmacology; Drug Screening Assays, Antitumor; Humans; Kinetics; Mycoplasma hyorhinis/genetics; Purine Nucleosides/metabolism; Purine Nucleosides/pharmacology; Purine-Nucleoside Phosphorylase/antagonists & inhibitors; Purine-Nucleoside Phosphorylase/genetics; Purines/metabolism; Structure-Activity Relationship; Substrate Specificity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Purines / Purine-Nucleoside Phosphorylase / Mycoplasma hyorhinis / Antineoplastic Agents Limits: Humans Language: En Journal: Mol Pharmacol Year: 2013 Document type: Article Affiliation country: Belgium

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