Distinct characteristics of inferonasal fundus autofluorescence patterns in stargardt disease and retinitis pigmentosa.
Invest Ophthalmol Vis Sci
; 54(10): 6820-6, 2013 Oct 17.
Article
in En
| MEDLINE
| ID: mdl-24071957
ABSTRACT
PURPOSE:
To report distinct characteristics of fundus autofluorescence (AF) patterns inferior to the optic disc in recessive Stargardt disease (STGD1) and retinitis pigmentosa (RP).METHODS:
Short-wavelength (SW) and near-infrared (NIR) AF images were acquired from patients with STGD1 and RP. In SW- and NIR-AF images of STGD1 patients, gray levels (GL) on both sides of the demarcation line were measured.RESULTS:
In STGD1, a demarcation line, which has been assigned to the closed optic fissure, was visible on SW-AF and NIR-AF inferior to the optic disc. In healthy subjects, this demarcation line is only visible by SW-AF. At 20° inferior to the disc center, AF levels on the nasal side were 25% (±11%) lower than on the temporal side in SW-AF images and 18% (±11%) lower in NIR-AF images. For both STGD1 and RP, the inferonasal quadrant exhibited distinct SW- and NIR-AF patterns compared with other fundus areas. Disease-related AF changes, such as flecks, appeared to respect the demarcation line as a boundary.CONCLUSIONS:
Disease-related AF patterns originating in RPE in STGD1 and RP appear to respect the demarcation line in the inferonasal quadrant of the fundus as a border. The visibility of the inferonasal demarcation line by NIR-AF in STGD1 but not in healthy eyes may indicate that increased levels of RPE lipofuscin modulate the melanin-related NIR-AF signal. This feature of NIR-AF images may aid in the diagnosis of STGD1 patients.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Optic Disk
/
Retinitis Pigmentosa
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Retinal Pigment Epithelium
/
Retinal Dystrophies
Limits:
Adolescent
/
Adult
/
Child
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Female
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
Invest Ophthalmol Vis Sci
Year:
2013
Document type:
Article