Synthesis and biological evaluation of thiophene-C-glucosides as sodium-dependent glucose cotransporter 2 inhibitors.
Chem Pharm Bull (Tokyo)
; 61(10): 1037-43, 2013.
Article
in En
| MEDLINE
| ID: mdl-24088695
ABSTRACT
The synthesis and structure-activity relationship (SAR) of thiophene-C-glucosides have been explored, and the human sodium-dependent glucose cotransporter 2 (hSGLT2) inhibitory activities and rat urinary glucose excretion (UGE) effects of 3a-f were evaluated. As a result, they showed good hSGLT2 inhibitory activities and rat UGE effects. In particular, the chlorothiophene derivative 3f showed remarkable inhibitory activity against hSGLT2.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sorbitol
/
Thiophenes
/
Sodium-Glucose Transporter 2 Inhibitors
/
Glucose
/
Glucosides
/
Hypoglycemic Agents
Limits:
Animals
/
Humans
/
Male
Language:
En
Journal:
Chem Pharm Bull (Tokyo)
Year:
2013
Document type:
Article