A phase II and biomarker study of ramucirumab, a human monoclonal antibody targeting the VEGF receptor-2, as first-line monotherapy in patients with advanced hepatocellular cancer.

Zhu, Andrew X; Finn, Richard S; Mulcahy, Mary; Gurtler, Jayne; Sun, Weijing; Schwartz, Jonathan D; Dalal, Rita P; Joshi, Adarsh; Hozak, Rebecca R; Xu, Yihuan; Ancukiewicz, Marek; Jain, Rakesh K; Nugent, Francis W; Duda, Dan G; Stuart, Keith

Zhu, Andrew X; Finn, Richard S; Mulcahy, Mary; Gurtler, Jayne; Sun, Weijing; Schwartz, Jonathan D; Dalal, Rita P; Joshi, Adarsh; Hozak, Rebecca R; Xu, Yihuan; Ancukiewicz, Marek; Jain, Rakesh K; Nugent, Francis W; Duda, Dan G; Stuart, Keith.

Affiliation

Zhu AX; Authors' Affiliations: Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts; David Geffen School of Medicine, University of California, Los Angeles, California; Northwestern University Feinberg School of Medicine, Chicago Illinois; East Jefferson General Hospital, Metairie, Louisiana; Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; ImClone Systems, a wholly-owned subsidiary of Eli Lilly and company, Br

Clin Cancer Res ; 19(23): 6614-23, 2013 Dec 01.

Article in En | MEDLINE | ID: mdl-24088738

Subject(s)

Antibodies, Monoclonal/therapeutic use; Antineoplastic Agents/therapeutic use; Biomarkers, Tumor/blood; Carcinoma, Hepatocellular/drug therapy; Liver Neoplasms/drug therapy; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal/pharmacology; Antibodies, Monoclonal, Humanized; Antineoplastic Agents/pharmacology; Carcinoma, Hepatocellular/blood; Carcinoma, Hepatocellular/mortality; Disease-Free Survival; Female; Humans; Kaplan-Meier Estimate; Liver Neoplasms/blood; Liver Neoplasms/mortality; Male; Middle Aged; Placenta Growth Factor; Pregnancy Proteins/blood; Proportional Hazards Models; Vascular Endothelial Growth Factor A/blood; Vascular Endothelial Growth Factor Receptor-2/antagonists & inhibitors; Vascular Endothelial Growth Factor Receptor-2/blood; Ramucirumab

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biomarkers, Tumor / Carcinoma, Hepatocellular / Liver Neoplasms / Antibodies, Monoclonal / Antineoplastic Agents Type of study: Prognostic_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2013 Document type: Article Affiliation country: Brazil Country of publication: United States

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