Pharmacokinetic-pharmacodynamic modeling of the anticancer effect of erlotinib in a human non-small cell lung cancer xenograft mouse model.

Wu, Qiong; Li, Meng-yao; Li, Han-qing; Deng, Chen-hui; Li, Liang; Zhou, Tian-yan; Lu, Wei

Wu, Qiong; Li, Meng-yao; Li, Han-qing; Deng, Chen-hui; Li, Liang; Zhou, Tian-yan; Lu, Wei.

Affiliation

Wu Q; Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China.

Acta Pharmacol Sin ; 34(11): 1427-36, 2013 Nov.

Article in En | MEDLINE | ID: mdl-24096601

Subject(s)

Carcinoma, Non-Small-Cell Lung/drug therapy; Lung Neoplasms/drug therapy; Models, Biological; Quinazolines/pharmacology; Animals; Antineoplastic Agents/administration & dosage; Antineoplastic Agents/pharmacokinetics; Antineoplastic Agents/pharmacology; Blotting, Western; Carcinoma, Non-Small-Cell Lung/pathology; Cell Line, Tumor; Chromatography, Liquid; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; ErbB Receptors/antagonists & inhibitors; ErbB Receptors/metabolism; Erlotinib Hydrochloride; Female; Humans; Inhibitory Concentration 50; Lung Neoplasms/pathology; Mice; Mice, Inbred BALB C; Phosphorylation/drug effects; Protein Kinase Inhibitors/administration & dosage; Protein Kinase Inhibitors/pharmacokinetics; Protein Kinase Inhibitors/pharmacology; Quinazolines/administration & dosage; Quinazolines/pharmacokinetics; Tandem Mass Spectrometry; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinazolines / Carcinoma, Non-Small-Cell Lung / Lung Neoplasms / Models, Biological Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Acta Pharmacol Sin Journal subject: FARMACOLOGIA Year: 2013 Document type: Article Affiliation country: China Country of publication: United States

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