A novel glutamate transporter blocker, LL-TBOA, attenuates ischaemic injury in the isolated, perfused rat heart despite low transporter levels.

Martinov, Vladimir; Dehnes, Yvette; Holmseth, Silvia; Shimamoto, Keiko; Danbolt, Niels Christian; Valen, Guro

Martinov, Vladimir; Dehnes, Yvette; Holmseth, Silvia; Shimamoto, Keiko; Danbolt, Niels Christian; Valen, Guro.

Affiliation

Martinov V; Department of Physiology, Institute of Basic Medical Science, University of Oslo, Oslo, Norway.

Eur J Cardiothorac Surg ; 45(4): 710-6, 2014 Apr.

Article in En | MEDLINE | ID: mdl-24099732

Subject(s)

Amino Acid Transport System X-AG/antagonists & inhibitors; Arrhythmias, Cardiac/drug therapy; Excitatory Amino Acid Antagonists/therapeutic use; Myocardial Reperfusion Injury/drug therapy; Animals; Arrhythmias, Cardiac/prevention & control; Aspartic Acid/analogs & derivatives; Aspartic Acid/chemistry; Aspartic Acid/pharmacology; Aspartic Acid/therapeutic use; Excitatory Amino Acid Antagonists/chemistry; Excitatory Amino Acid Antagonists/pharmacology; Heart Ventricles/drug effects; Myocardial Infarction/drug therapy; Myocardial Reperfusion Injury/pathology; Rats

Key words

Ischaemia-reperfusion; Myocardial protection; Reperfusion arrhythmias

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arrhythmias, Cardiac / Myocardial Reperfusion Injury / Excitatory Amino Acid Antagonists / Amino Acid Transport System X-AG Limits: Animals Language: En Journal: Eur J Cardiothorac Surg Journal subject: CARDIOLOGIA Year: 2014 Document type: Article Affiliation country: Norway Country of publication: Germany

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