Immunologic pathomechanism of Hodgkin's lymphoma.
Exp Hematol
; 41(12): 995-1004, 2013 Dec.
Article
in En
| MEDLINE
| ID: mdl-24099823
ABSTRACT
Hodgkin's lymphoma is a lymphoid malignancy of the immune system. The pathognomonic Hodgkin and Reed-Sternberg cells (HRS) are derived mainly from monoclonal, preapoptotic B cells, and they carry rearranged, somatically mutated immunoglobulin heavy chains. In an appropriate microenvironment, HRS cells escape from apoptosis by several mechanisms, including single mutations, aberrant signaling pathways. Eventually, weakened immune surveillance leads to uncontrolled, disproportional B cell proliferation. This review summarizes the latest findings on the pathogenesis of Hodgkin lymphoma, with a special emphasis on immunologic processes, and depicts current and future immunotherapeutic regimens, which improve treatment outcomes and reduce late toxicities.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hodgkin Disease
/
Genes, Immunoglobulin
/
B-Lymphocytes
Limits:
Humans
Language:
En
Journal:
Exp Hematol
Year:
2013
Document type:
Article