Effects of substitutions at the 4' and 2 positions on the bioactivity of 4'-ethynyl-2-fluoro-2'-deoxyadenosine.

Kirby, Karen A; Michailidis, Eleftherios; Fetterly, Tracy L; Steinbach, Musetta A; Singh, Kamalendra; Marchand, Bruno; Leslie, Maxwell D; Hagedorn, Ariel N; Kodama, Eiichi N; Marquez, Victor E; Hughes, Stephen H; Mitsuya, Hiroaki; Parniak, Michael A; Sarafianos, Stefan G

Kirby, Karen A; Michailidis, Eleftherios; Fetterly, Tracy L; Steinbach, Musetta A; Singh, Kamalendra; Marchand, Bruno; Leslie, Maxwell D; Hagedorn, Ariel N; Kodama, Eiichi N; Marquez, Victor E; Hughes, Stephen H; Mitsuya, Hiroaki; Parniak, Michael A; Sarafianos, Stefan G.

Affiliation

Kirby KA; Christopher Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA.

Antimicrob Agents Chemother ; 57(12): 6254-64, 2013 Dec.

Article in En | MEDLINE | ID: mdl-24100493

Subject(s)

Deoxyadenosines/chemistry; Deoxyadenosines/pharmacology; HIV Reverse Transcriptase/antagonists & inhibitors; HIV Reverse Transcriptase/metabolism; HIV-1/drug effects; Humans; Kinetics; Magnetic Resonance Spectroscopy; Molecular Conformation; Reverse Transcriptase Inhibitors/chemistry; Reverse Transcriptase Inhibitors/pharmacology; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Deoxyadenosines Limits: Humans Language: En Journal: Antimicrob Agents Chemother Year: 2013 Document type: Article Affiliation country: United States Country of publication: United States

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