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The E693Δ (Osaka) mutation in amyloid precursor protein potentiates cholesterol-mediated intracellular amyloid ß toxicity via its impaired cholesterol efflux.
Nomura, Sachiko; Umeda, Tomohiro; Tomiyama, Takami; Mori, Hiroshi.
Affiliation
  • Nomura S; Department of Neuroscience, Osaka City University Graduate School of Medicine, Osaka, Japan; Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Tokyo, Japan.
J Neurosci Res ; 91(12): 1541-50, 2013 Dec.
Article in En | MEDLINE | ID: mdl-24105984

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cholesterol / Amyloid beta-Peptides / Amyloid beta-Protein Precursor / Protein Transport / Mutation Limits: Humans Language: En Journal: J Neurosci Res Year: 2013 Document type: Article Affiliation country: Japan Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cholesterol / Amyloid beta-Peptides / Amyloid beta-Protein Precursor / Protein Transport / Mutation Limits: Humans Language: En Journal: J Neurosci Res Year: 2013 Document type: Article Affiliation country: Japan Country of publication: United States