Glycyrrhizinate reduces portal hypertension in isolated perfused rat livers with chronic hepatitis.

Zhao, Xin; Deng, Bo; Xu, Xue-Yan; Yang, Shi-Jun; Zhang, Tao; Song, Yi-Jun; Liu, Xiao-Ting; Wang, Yue-Qi; Cai, Da-Yong

Zhao, Xin; Deng, Bo; Xu, Xue-Yan; Yang, Shi-Jun; Zhang, Tao; Song, Yi-Jun; Liu, Xiao-Ting; Wang, Yue-Qi; Cai, Da-Yong.

Affiliation

Zhao X; Xin Zhao, Bo Deng, Xue-Yan Xu, Shi-Jun Yang, Tao Zhang, Da-Yong Cai, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China.

World J Gastroenterol ; 19(36): 6069-76, 2013 Sep 28.

Article in En | MEDLINE | ID: mdl-24106408

Subject(s)

Antihypertensive Agents/pharmacology; Chemical and Drug Induced Liver Injury, Chronic/drug therapy; Glycyrrhizic Acid/pharmacology; Hypertension, Portal/drug therapy; Liver/blood supply; Liver/drug effects; Portal Pressure/drug effects; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury, Chronic/etiology; Chemical and Drug Induced Liver Injury, Chronic/metabolism; Chemical and Drug Induced Liver Injury, Chronic/physiopathology; Collagen/metabolism; Dose-Response Relationship, Drug; Hypertension, Portal/etiology; Hypertension, Portal/metabolism; Hypertension, Portal/physiopathology; Liver/metabolism; Liver/pathology; Liver Cirrhosis, Experimental/drug therapy; Liver Cirrhosis, Experimental/etiology; Liver Cirrhosis, Experimental/metabolism; Liver Cirrhosis, Experimental/physiopathology; Macrophages/drug effects; Macrophages/metabolism; Male; Nitric Oxide Synthase Type II/metabolism; Perfusion; Peroxynitrous Acid/metabolism; Rats; Rats, Wistar; Time Factors

Key words

Chronic hepatitis; Diammonium glycyrrhizinate; Inducible nitric oxide synthase; Isolated portal perfused rat liver; Portal hypertension

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Portal Pressure / Glycyrrhizic Acid / Chemical and Drug Induced Liver Injury, Chronic / Hypertension, Portal / Liver / Antihypertensive Agents Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: World J Gastroenterol Journal subject: GASTROENTEROLOGIA Year: 2013 Document type: Article Affiliation country: China Country of publication: United States

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