Methyl-thiazoles: a novel mode of inhibition with the potential to develop novel inhibitors targeting InhA in Mycobacterium tuberculosis.

Shirude, Pravin S; Madhavapeddi, Prashanti; Naik, Maruti; Murugan, Kannan; Shinde, Vikas; Nandishaiah, Radha; Bhat, Jyothi; Kumar, Anupriya; Hameed, Shahul; Holdgate, Geoffrey; Davies, Gareth; McMiken, Helen; Hegde, Naina; Ambady, Anisha; Venkatraman, Janani; Panda, Manoranjan; Bandodkar, Balachandra; Sambandamurthy, Vasan K; Read, Jon A

Shirude, Pravin S; Madhavapeddi, Prashanti; Naik, Maruti; Murugan, Kannan; Shinde, Vikas; Nandishaiah, Radha; Bhat, Jyothi; Kumar, Anupriya; Hameed, Shahul; Holdgate, Geoffrey; Davies, Gareth; McMiken, Helen; Hegde, Naina; Ambady, Anisha; Venkatraman, Janani; Panda, Manoranjan; Bandodkar, Balachandra; Sambandamurthy, Vasan K; Read, Jon A.

Affiliation

Shirude PS; Department of Medicinal Chemistry, Department of Biosciences, AstraZeneca India Pvt. Ltd. , Bellary Road, Hebbal, Bangalore-560024, India.

J Med Chem ; 56(21): 8533-42, 2013 Nov 14.

Article in En | MEDLINE | ID: mdl-24107081

Subject(s)

Bacterial Proteins/antagonists & inhibitors; Enzyme Inhibitors/pharmacology; Mycobacterium tuberculosis/enzymology; Oxidoreductases/antagonists & inhibitors; Thiazoles/pharmacology; Bacterial Proteins/metabolism; Crystallography, X-Ray; Dose-Response Relationship, Drug; Enzyme Inhibitors/chemical synthesis; Enzyme Inhibitors/chemistry; Models, Molecular; Molecular Structure; Oxidoreductases/metabolism; Structure-Activity Relationship; Thiazoles/chemical synthesis; Thiazoles/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxidoreductases / Thiazoles / Bacterial Proteins / Enzyme Inhibitors / Mycobacterium tuberculosis Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2013 Document type: Article Affiliation country: India

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