Tetherin upregulation in simian immunodeficiency virus-infected macaques.
J Virol
; 87(24): 13917-21, 2013 Dec.
Article
in En
| MEDLINE
| ID: mdl-24109219
ABSTRACT
Here we show that simian immunodeficiency virus (SIV) infection of rhesus macaques results in rapid upregulation of tetherin (BST-2 or CD317) on peripheral blood lymphocytes, including the CD4(+) CCR5(+) T cell targets of virus infection, with a peak of induction that coincides with peak alpha interferon (IFN-α) levels in plasma, and that tetherin remains above baseline levels throughout chronic infection. These observations are consistent with a role for tetherin in innate immunity to immunodeficiency virus infection.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antigens, CD
/
Up-Regulation
/
Simian Acquired Immunodeficiency Syndrome
/
Simian Immunodeficiency Virus
Limits:
Animals
Language:
En
Journal:
J Virol
Year:
2013
Document type:
Article
Affiliation country:
United States