1-Naphthylisothiocyanate/toxicity; Hepatocytes/drug effects; ATP-Binding Cassette Transporters/physiology; Animals; Bile Acids and Salts/metabolism; Biological Transport/drug effects; Cells, Cultured; Hepatocytes/metabolism; Male; Metabolome; Rats; Rats, Sprague-Dawley

5 (and 6)-carboxy-2',7'-dichlorofluorescein; 5 (and 6)-carboxy-2',7'-dichlorofluorescein diacetate; ALT; ANIT; Alpha-naphthylisothiocyanate; BECs; BEI; Bsep; CDF; CDFDA; Cl(biliary); Cyp27a1; Cyp7a1; Cyp8b1; DPDPE; Drug-induced cholestasis; ELISA; GC­MS; HBSS; Hank's balanced salt solution; IPRLs; LC­MS/MS; LDH; Mrp; Ntcp; Oatp; PLS-DA; SCRH; Sandwich-cultured hepatocytes; Transporter; VPA; [D-Pen(2,5)]-enkephalin; alanine transaminase; alpha-naphthylisothiocyanate; bile salt export pump; biliary clearance; biliary epithelial cells; biliary excretion index; cholesterol 7α-hydroxylase; d8-TCA; deuterium-labeled sodium taurocholate; enzyme-linked immunosorbent assay; gas chromatography­mass spectrometry; isolated perfused rat livers; lactate dehydrogenase; liquid chromatography­mass spectrometry tandem mass spectrometry; multidrug resistance-associated protein; organic anion transporting polypeptide; partial least squares discriminant analysis; sandwich-cultured rat hepatocytes; sodium/taurocholate cotransporting polypeptide; sterol 12α-hydroxylase; sterol 27-hydroxylase; valproic acid