DMSO-mediated ligand dissociation: renaissance for biological activity of N-heterocyclic-[Ru(Î·6-arene)Cl2] drug candidates.

Patra, Malay; Joshi, Tanmaya; Pierroz, Vanessa; Ingram, Katrin; Kaiser, Marcel; Ferrari, Stefano; Spingler, Bernhard; Keiser, Jennifer; Gasser, Gilles

Patra, Malay; Joshi, Tanmaya; Pierroz, Vanessa; Ingram, Katrin; Kaiser, Marcel; Ferrari, Stefano; Spingler, Bernhard; Keiser, Jennifer; Gasser, Gilles.

Affiliation

Patra M; Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich (Switzerland). malay.patra@uzh.ch.

Chemistry ; 19(44): 14768-72, 2013 Oct 25.

Article in En | MEDLINE | ID: mdl-24123460

Subject(s)

Coordination Complexes/chemistry; Coordination Complexes/pharmacology; Dimethyl Sulfoxide/chemistry; Heterocyclic Compounds/chemistry; Heterocyclic Compounds/pharmacology; Ruthenium/chemistry; Ruthenium/pharmacology; Animals; Humans; Ligands; Rats

Key words

N-heterocycles; bioorganometallic chemistry; dimethyl sulfoxide; ligand exchange; ruthenium

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ruthenium / Dimethyl Sulfoxide / Coordination Complexes / Heterocyclic Compounds Limits: Animals / Humans Language: En Journal: Chemistry Journal subject: QUIMICA Year: 2013 Document type: Article

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