High-throughput screening (HTS) and hit validation to identify small molecule inhibitors with activity against NS3/4A proteases from multiple hepatitis C virus genotypes.

Lee, Hyun; Zhu, Tian; Patel, Kavankumar; Zhang, Yan-Yan; Truong, Lena; Hevener, Kirk E; Gatuz, Joseph L; Subramanya, Gitanjali; Jeong, Hyun-Young; Uprichard, Susan L; Johnson, Michael E

Lee, Hyun; Zhu, Tian; Patel, Kavankumar; Zhang, Yan-Yan; Truong, Lena; Hevener, Kirk E; Gatuz, Joseph L; Subramanya, Gitanjali; Jeong, Hyun-Young; Uprichard, Susan L; Johnson, Michael E.

Affiliation

Lee H; Center for Pharmaceutical Biotechnology and Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois, United States of America.

PLoS One ; 8(10): e75144, 2013.

Article in En | MEDLINE | ID: mdl-24130685

Subject(s)

Antiviral Agents/pharmacology; Hepacivirus/enzymology; Protease Inhibitors/pharmacology; Viral Nonstructural Proteins/antagonists & inhibitors; Amino Acid Sequence; Drug Evaluation, Preclinical/methods; Hepacivirus/drug effects; Molecular Sequence Data; Sequence Homology, Amino Acid

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Protease Inhibitors / Viral Nonstructural Proteins / Hepacivirus Type of study: Diagnostic_studies / Screening_studies Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2013 Document type: Article Affiliation country: United States Country of publication: United States

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