Ascertaining the suitability of aryl sulfonyl fluorides for [18F]radiochemistry applications: a systematic investigation using microfluidics.
J Org Chem
; 78(22): 11262-70, 2013 Nov 15.
Article
in En
| MEDLINE
| ID: mdl-24134549
ABSTRACT
Optimization of [(18)F]radiolabeling conditions and subsequent stability analysis in mobile phase, PBS buffer, and rat serum of 12 aryl sulfonyl chloride precursors with various substituents (electron-withdrawing groups, electron-donating groups, increased steric bulk, heterocyclic) were performed using an Advion NanoTek Microfluidic Synthesis System. A comparison of radiochemical yields and reaction times for a microfluidics device versus a conventional reaction vessel is reported. [(18)F]Radiolabeling of sulfonyl chlorides in the presence of competing nucleophiles, H-bond donors, and water was also assessed and demonstrated the versatility and potential utility of [(18)F]sulfonyl fluorides as synthons for indirect radiolabeling.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sulfinic Acids
/
Fluorine Radioisotopes
/
Microfluidic Analytical Techniques
/
Hydrocarbons, Fluorinated
Limits:
Animals
Language:
En
Journal:
J Org Chem
Year:
2013
Document type:
Article
Affiliation country:
Australia