Elevation of seizure threshold after intranasal administration of anti-glutamate antibodies to C57BL/6 mice.
Bull Exp Biol Med
; 155(3): 309-11, 2013 Jul.
Article
in En
| MEDLINE
| ID: mdl-24137590
ABSTRACT
The dose-dependent effect of intranasal administration of antibodies to glutamate on acute generalized epileptic activity was studied in C57Bl/6 mice. It was shown that pretreatment with antibodies in doses of 100, 300, and 500 µg/kg 1 h before titration with convulsant pentylenetetrazole had anticonvulsant effects. This treatment was followed by an increase in the thresholds of clonic and tonic seizures with fatal outcome and lengthening of seizure latency. The most pronounced effect was observed in doses of 300 and 500 µg/kg. Comparison of the anticonvulsant effect of antibodies in active immunization with glutamate-BSA conjugate and systemic intraperitoneal administration of purified anti-glutamate antibodies revealed advantages of intranasal administration.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Seizures
/
Glutamic Acid
/
Antibodies
/
Anticonvulsants
Limits:
Animals
Language:
En
Journal:
Bull Exp Biol Med
Year:
2013
Document type:
Article
Affiliation country:
RUSSIA