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Non-high-density lipoprotein cholesterol: distribution and prevalence of high serum levels in children and adolescents: United States National Health and Nutrition Examination Surveys, 2005-2010.
Dai, Shifan; Yang, Quanhe; Yuan, Keming; Loustalot, Fleetwood; Fang, Jing; Daniels, Stephen R; Hong, Yuling.
Affiliation
  • Dai S; Division of Nutrition, Physical Activity, and Obesity, Centers for Disease Control and Prevention, Atlanta, GA. Electronic address: sdai@cdc.gov.
  • Yang Q; Division for Heart Disease and Stroke Prevention, Centers for Disease Control and Prevention, Atlanta, GA.
  • Yuan K; Division for Heart Disease and Stroke Prevention, Centers for Disease Control and Prevention, Atlanta, GA.
  • Loustalot F; Division for Heart Disease and Stroke Prevention, Centers for Disease Control and Prevention, Atlanta, GA.
  • Fang J; Division for Heart Disease and Stroke Prevention, Centers for Disease Control and Prevention, Atlanta, GA.
  • Daniels SR; Department of Pediatrics, University of Colorado School of Medicine, Children's Hospital Colorado, Aurora, CO.
  • Hong Y; Division for Heart Disease and Stroke Prevention, Centers for Disease Control and Prevention, Atlanta, GA.
J Pediatr ; 164(2): 247-53, 2014 Feb.
Article in En | MEDLINE | ID: mdl-24139441
OBJECTIVES: To estimate age-related changes for serum concentration of non-high-density lipoprotein cholesterol (HDL-C), describe non-HDL-C distribution, and examine the prevalence of high non-HDL-C levels in children and adolescents by demographic characteristics and weight status. STUDY DESIGN: Data from 7058 participants ages 6-19 years in the 2005-2010 National Health and Nutrition Examination Surveys were analyzed. A high level of non-HDL-C was defined as a non-HDL-C value ≥ 145 mg/dL. RESULTS: Locally weighted scatterplot smoothing-smoothed curves showed that non-HDL-C levels increased from 101 mg/dL at age 6 to 111 mg/dL at age 10, decreased to 101 mg/dL at age 14, and then increased to 122 mg/dL at age 19 in non-Hispanic white males. Non-HDL-C levels generally were greater in female than male subjects, lower in non-Hispanic black subjects, and similar in male and slightly lower in female Mexican American subjects, compared with non-Hispanic white subjects. The overall mean was 108 (SE 0.5), and the percentiles were 67 (5th), 74 (10th), 87 (25th), 104 (50th), 123 (75th), 145 (90th), and 158 (95th) mg/dL. Mean and percentiles were greater among age groups 9-11 and 17-19 years than others and greater among non-Hispanic white than non-Hispanic black subjects. The prevalence of high non-HDL-C was 11.8% (95% CI 9.9%-14.0%) and 15.0% (95% CI 12.9%-17.3%) for the age groups 9-11 and 17-19, respectively. It varied significantly by race/ethnicity and overweight/obesity status. CONCLUSION: Non-HDL-C levels vary by age, sex, race/ethnicity, and weight classification status. Evaluation of non-HDL-C in youth should account for its normal physiologic patterns and variations in demographic characteristics and weight classification.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ethnicity / Nutrition Surveys / Dyslipidemias / Cholesterol, HDL Type of study: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limits: Adolescent / Adult / Child / Female / Humans / Male Country/Region as subject: America do norte Language: En Journal: J Pediatr Year: 2014 Document type: Article Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ethnicity / Nutrition Surveys / Dyslipidemias / Cholesterol, HDL Type of study: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limits: Adolescent / Adult / Child / Female / Humans / Male Country/Region as subject: America do norte Language: En Journal: J Pediatr Year: 2014 Document type: Article Country of publication: United States