Titanium mediated olefination of aldehydes with α-haloacetates: an exceptionally stereoselective and general approach to (Z)-α-haloacrylates.
Org Biomol Chem
; 11(46): 8065-72, 2013 Dec 14.
Article
in En
| MEDLINE
| ID: mdl-24145668
ABSTRACT
An exceptionally stereoselective and general synthesis of (Z)-α-haloacrylates, ready to undergo various synthetic transformations, has been demonstrated from α-haloacetates and aldehydes in a one-pot manner via the titanium-enolate based asymmetric aldol condensation. Besides being an expedient synthetic procedure, the ready availability of diverse α-haloacetates, exceptional stereoselectivity, and high yields make the process a versatile transformation in organic synthesis. The potential of this method in up-scaling operations has been illustrated.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Titanium
/
Acrylates
/
Aldehydes
/
Alkenes
/
Hydrocarbons, Halogenated
/
Acetates
Language:
En
Journal:
Org Biomol Chem
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2013
Document type:
Article