Targeted gene deletion of miRNAs in mice by TALEN system.

Takada, Shuji; Sato, Tempei; Ito, Yoshiaki; Yamashita, Satoshi; Kato, Tomoko; Kawasumi, Miyuri; Kanai-Azuma, Masami; Igarashi, Arisa; Kato, Tomomi; Tamano, Moe; Asahara, Hiroshi

Takada, Shuji; Sato, Tempei; Ito, Yoshiaki; Yamashita, Satoshi; Kato, Tomoko; Kawasumi, Miyuri; Kanai-Azuma, Masami; Igarashi, Arisa; Kato, Tomomi; Tamano, Moe; Asahara, Hiroshi.

Affiliation

Takada S; Department of Systems BioMedicine, National Research Institute for Child Health and Development, Tokyo, Japan.

PLoS One ; 8(10): e76004, 2013.

Article in En | MEDLINE | ID: mdl-24146809

Subject(s)

DNA-Binding Proteins/genetics; Deoxyribonucleases, Type II Site-Specific/genetics; Gene Deletion; Gene Targeting/methods; MicroRNAs/genetics; Recombinant Fusion Proteins/genetics; Animals; Base Sequence; DNA, Intergenic/genetics; DNA, Intergenic/metabolism; DNA-Binding Proteins/metabolism; Deoxyribonucleases, Type II Site-Specific/metabolism; Embryo, Mammalian; Female; Genetic Engineering; Mice; Mice, Inbred ICR; MicroRNAs/metabolism; Microinjections; Molecular Sequence Data; Oocytes/cytology; Oocytes/growth & development; Oocytes/metabolism; Recombinant Fusion Proteins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Recombinant Fusion Proteins / Deoxyribonucleases, Type II Site-Specific / Gene Deletion / Gene Targeting / MicroRNAs / DNA-Binding Proteins Limits: Animals Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2013 Document type: Article Affiliation country: Japan Country of publication: United States

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