Dolutegravir interactions with HIV-1 integrase-DNA: structural rationale for drug resistance and dissociation kinetics.

DeAnda, Felix; Hightower, Kendra E; Nolte, Robert T; Hattori, Kazunari; Yoshinaga, Tomokazu; Kawasuji, Takashi; Underwood, Mark R

DeAnda, Felix; Hightower, Kendra E; Nolte, Robert T; Hattori, Kazunari; Yoshinaga, Tomokazu; Kawasuji, Takashi; Underwood, Mark R.

Affiliation

DeAnda F; Chemical Sciences, GlaxoSmithKline, Research Triangle Park, North Carolina, United States of America.

PLoS One ; 8(10): e77448, 2013.

Article in En | MEDLINE | ID: mdl-24146996

Subject(s)

HIV Integrase Inhibitors/metabolism; HIV Integrase/genetics; HIV-1/genetics; HIV-1/metabolism; Heterocyclic Compounds, 3-Ring/metabolism; Proviruses/genetics; Drug Resistance, Viral/genetics; HIV Integrase/metabolism; HIV Integrase Inhibitors/chemistry; HIV Integrase Inhibitors/pharmacology; HIV Long Terminal Repeat/genetics; HIV-1/drug effects; Heterocyclic Compounds, 3-Ring/chemistry; Heterocyclic Compounds, 3-Ring/pharmacology; Humans; Kinetics; Models, Molecular; Molecular Docking Simulation; Molecular Structure; Nucleic Acid Conformation; Oxazines; Piperazines; Protein Binding; Protein Conformation; Pyridones

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV-1 / Proviruses / HIV Integrase Inhibitors / HIV Integrase / Heterocyclic Compounds, 3-Ring Type of study: Prognostic_studies Limits: Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2013 Document type: Article Affiliation country: United States Country of publication: United States

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