The TOMM machinery is a molecular switch in PINK1 and PARK2/PARKIN-dependent mitochondrial clearance.

Bertolin, Giulia; Ferrando-Miguel, Rosa; Jacoupy, Maxime; Traver, Sabine; Grenier, Karl; Greene, Andrew W; Dauphin, Aurélien; Waharte, François; Bayot, Aurélien; Salamero, Jean; Lombès, Anne; Bulteau, Anne-Laure; Fon, Edward A; Brice, Alexis; Corti, Olga

Bertolin, Giulia; Ferrando-Miguel, Rosa; Jacoupy, Maxime; Traver, Sabine; Grenier, Karl; Greene, Andrew W; Dauphin, Aurélien; Waharte, François; Bayot, Aurélien; Salamero, Jean; Lombès, Anne; Bulteau, Anne-Laure; Fon, Edward A; Brice, Alexis; Corti, Olga.

Affiliation

Bertolin G; Inserm; U 975; CRICM; Hôpital de la Pitié-Salpêtrière; Paris, France; UPMC; Université Paris 06; UMR_S975; Paris, France; CNRS; UMR 7225; Paris, France.

Autophagy ; 9(11): 1801-17, 2013 Nov 01.

Article in En | MEDLINE | ID: mdl-24149440

Subject(s)

Membrane Transport Proteins/metabolism; Mitochondria/metabolism; Mitochondrial Membrane Transport Proteins/metabolism; Protein Kinases/metabolism; Ubiquitin-Protein Ligases/metabolism; Down-Regulation; HEK293 Cells; HeLa Cells; Humans; Mitochondrial Membranes/metabolism; Mitochondrial Precursor Protein Import Complex Proteins; Mitophagy; Models, Biological; Mutation/genetics; Parkinson Disease/genetics; Protein Binding; Protein Transport; Signal Transduction

Key words

PARK2; PINK1; Parkinson disease; TOMM machinery; mitochondria; mitophagy; outer mitochondrial membrane

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Membrane Transport Proteins / Protein Kinases / Mitochondrial Membrane Transport Proteins / Ubiquitin-Protein Ligases / Mitochondria Limits: Humans Language: En Journal: Autophagy Year: 2013 Document type: Article Affiliation country: France Country of publication: United States

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