Highly enantioselective decarboxylative Mannich reaction of malonic acid half oxyesters with cyclic trifluoromethyl ketimines: synthesis of ß-amino esters and anti-HIV drug DPC 083.

Yuan, Hai-Na; Li, Shen; Nie, Jing; Zheng, Yan; Ma, Jun-An

Yuan, Hai-Na; Li, Shen; Nie, Jing; Zheng, Yan; Ma, Jun-An.

Affiliation

Yuan HN; Department of Chemistry, Key Laboratory of Systems, Bioengineering (The Ministry of Education), State Synergetic, Innovation Center of Chemical Science and Engineering, Tianjin University, Tianjin 300072 (P. R. of China), Fax: (+86) 22-2740-3475.

Chemistry ; 19(47): 15856-60, 2013 Nov 18.

Article in En | MEDLINE | ID: mdl-24150893

Subject(s)

Anti-HIV Agents/chemical synthesis; Imines/chemistry; Malonates/chemistry; Nitriles/chemistry; Quinazolines/chemical synthesis; Anti-HIV Agents/chemistry; Catalysis; Crystallography, X-Ray; Cyclization; Esters; Molecular Conformation; Quinazolines/chemistry; Stereoisomerism

Key words

asymmetric catalysis; decarboxylative Mannich reaction; malonic acid half oxyesters; saccharide-derived amino-thioureas; ß-amino esters

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinazolines / Anti-HIV Agents / Imines / Malonates / Nitriles Language: En Journal: Chemistry Journal subject: QUIMICA Year: 2013 Document type: Article Country of publication: Germany

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