Activated protein C analog protects from ischemic stroke and extends the therapeutic window of tissue-type plasminogen activator in aged female mice and hypertensive rats.

Wang, Yaoming; Zhao, Zhen; Chow, Nienwen; Rajput, Padmesh S; Griffin, John H; Lyden, Patrick D; Zlokovic, Berislav V

Wang, Yaoming; Zhao, Zhen; Chow, Nienwen; Rajput, Padmesh S; Griffin, John H; Lyden, Patrick D; Zlokovic, Berislav V.

Affiliation

Wang Y; From the Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA (Y.W., Z.Z., B.V.Z.); ZZ Biotech Research Laboratory, Rochester, NY (N.C.); Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA (P.S.R., P.D.L.); and Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA (J.H.G.).

Stroke ; 44(12): 3529-36, 2013 Dec.

Article in En | MEDLINE | ID: mdl-24159062

Subject(s)

Brain Ischemia/drug therapy; Fibrinolytic Agents/therapeutic use; Neuroprotective Agents/therapeutic use; Stroke/drug therapy; Tissue Plasminogen Activator/therapeutic use; Animals; Brain/drug effects; Brain/pathology; Brain Ischemia/pathology; Drug Interactions; Female; Fibrinolytic Agents/pharmacology; Male; Mice; Neuroprotective Agents/pharmacology; Protein C/pharmacology; Protein C/therapeutic use; Rats; Rats, Inbred SHR; Stroke/pathology; Time Factors; Tissue Plasminogen Activator/pharmacology

Key words

neuroprotectant; protein C; rats, spontaneously hypertensive; stroke

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Ischemia / Tissue Plasminogen Activator / Neuroprotective Agents / Stroke / Fibrinolytic Agents Type of study: Guideline / Prognostic_studies Limits: Animals Language: En Journal: Stroke Year: 2013 Document type: Article Country of publication: United States

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