Similar activity of mecamylamine stereoisomers in vitro and in vivo.

Papke, Roger L; Stokes, Clare; Muldoon, Pretal; Imad Damaj, M

Papke, Roger L; Stokes, Clare; Muldoon, Pretal; Imad Damaj, M.

Affiliation

Papke RL; Department of Pharmacology and Therapeutics, University of Florida, College of Medicine, Gainesville, Florida, USA. Electronic address: rlpapke@ufl.edu.

Eur J Pharmacol ; 720(1-3): 264-75, 2013 Nov 15.

Article in En | MEDLINE | ID: mdl-24161916

Subject(s)

Mecamylamine/pharmacology; Nicotinic Antagonists/pharmacology; Receptors, Nicotinic/physiology; Analgesics/chemistry; Analgesics/pharmacology; Analgesics/therapeutic use; Animals; Hot Temperature; Humans; Male; Mecamylamine/chemistry; Mecamylamine/therapeutic use; Mice; Mice, Inbred ICR; Nicotinic Antagonists/chemistry; Nicotinic Antagonists/therapeutic use; Oocytes/physiology; Pain/drug therapy; Protein Subunits/physiology; Stereoisomerism; Xenopus laevis

Key words

Depression; Nicotine addiction; TC-2559; TC-5214; Tourette's syndrome

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Nicotinic / Nicotinic Antagonists / Mecamylamine Limits: Animals / Humans / Male Language: En Journal: Eur J Pharmacol Year: 2013 Document type: Article Country of publication: Netherlands

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