[Regulation of intracellular signal pathways via sensor proteins by oxidative stress].
Clin Calcium
; 23(11): 1613-9, 2013 Nov.
Article
in Ja
| MEDLINE
| ID: mdl-24162601
ABSTRACT
It has been known that reactive oxygen species (ROS) control the enzymatic and transcriptional activity of proteins via direct modification of cysteine residues. Hence, oxidation of cysteine thiol could be a vital modulator of signal transduction pathways. These findings indicate that some proteins serve as the sensor proteins highly sensitive to ROS. In this review, I show the relationship between intracellular ROS sensor and the regulation of protein function via oxidation.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Signal Transduction
/
Oxidative Stress
/
Intracellular Signaling Peptides and Proteins
/
NF-E2-Related Factor 2
Limits:
Animals
/
Humans
Language:
Ja
Journal:
Clin Calcium
Journal subject:
METABOLISMO
Year:
2013
Document type:
Article
Affiliation country:
Japan