Knock-down of filaggrin does not affect lipid organization and composition in stratum corneum of reconstructed human skin equivalents.

van Drongelen, Vincent; Alloul-Ramdhani, Mariam; Danso, Mogbekeloluwa O; Mieremet, Arnout; Mulder, Aat; van Smeden, Jeroen; Bouwstra, Joke A; El Ghalbzouri, Abdoelwaheb

van Drongelen, Vincent; Alloul-Ramdhani, Mariam; Danso, Mogbekeloluwa O; Mieremet, Arnout; Mulder, Aat; van Smeden, Jeroen; Bouwstra, Joke A; El Ghalbzouri, Abdoelwaheb.

Affiliation

van Drongelen V; Gorlaeus Laboratories, Department of Drug Delivery Technology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands; Department of Dermatology, Leiden University Medical Centre, Leiden, the Netherlands.

Exp Dermatol ; 22(12): 807-12, 2013 Dec.

Article in En | MEDLINE | ID: mdl-24164439

Subject(s)

Intermediate Filament Proteins/metabolism; Lipids/chemistry; Skin/pathology; Cell Proliferation; Dermatitis, Atopic/pathology; Epidermis/metabolism; Fibroblasts/metabolism; Filaggrin Proteins; Gene Knockdown Techniques; Heterozygote; Humans; Inflammation; Intermediate Filament Proteins/genetics; Keratin-10/metabolism; Keratins/metabolism; Ki-67 Antigen/metabolism; Membrane Proteins/metabolism; Permeability; Phenotype; Skin Diseases/pathology

Key words

N/TERT; filaggrin; skin barrier; skin equivalent; stratum corneum

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Skin / Intermediate Filament Proteins / Lipids Limits: Humans Language: En Journal: Exp Dermatol Journal subject: DERMATOLOGIA Year: 2013 Document type: Article Affiliation country: Netherlands Country of publication: Denmark

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