Concentration-dependent bimodal effect of specific 18 kDa translocator protein (TSPO) ligands on cell death processes induced by ammonium chloride: potential implications for neuropathological effects due to hyperammonemia.

Caballero, Beatriz; Veenman, Leo; Bode, Julia; Leschiner, Svetlana; Gavish, Moshe

Caballero, Beatriz; Veenman, Leo; Bode, Julia; Leschiner, Svetlana; Gavish, Moshe.

Affiliation

Gavish M; Rappaport Family Institute for Research in the Medical Sciences, Technion-Israel Institute of Technology, Department of Molecular Pharmacology, Ephron Street, P.O. Box 9649, Bat-Galim, Haifa 31096, Israel;. mgavish@techunix.technion.ac.il.

CNS Neurol Disord Drug Targets ; 13(4): 574-92, 2014.

Article in En | MEDLINE | ID: mdl-24168369

Subject(s)

Ammonium Chloride/toxicity; Cell Death/drug effects; Cell Death/physiology; Hyperammonemia/physiopathology; Receptors, GABA/metabolism; Benzodiazepinones/pharmacology; Cardiolipins/metabolism; Cell Line, Tumor; Cell Shape; Dose-Response Relationship, Drug; GABA Agents/pharmacology; Glutamine/metabolism; Humans; Hyperammonemia/chemically induced; Hyperammonemia/drug therapy; Indoleacetic Acids/pharmacology; Isoquinolines/metabolism; Isoquinolines/pharmacology; L-Lactate Dehydrogenase/metabolism; Ligands; Lipid Peroxidation/drug effects; Membrane Potential, Mitochondrial/drug effects; Membrane Potential, Mitochondrial/physiology; Mitochondria/drug effects; Mitochondria/physiology; Neuroprotective Agents/pharmacology; Propidium/chemistry

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Collection: 01-internacional Database: MEDLINE Main subject: Cell Death / Receptors, GABA / Hyperammonemia / Ammonium Chloride Limits: Humans Language: En Journal: CNS Neurol Disord Drug Targets Journal subject: NEUROLOGIA / TERAPIA POR MEDICAMENTOS Year: 2014 Document type: Article

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