Disturbed tumor necrosis factor system is linked with lower eGFR and chronic inflammation in hypertension.
Int J Biol Markers
; 29(1): e69-77, 2014.
Article
in En
| MEDLINE
| ID: mdl-24170558
ABSTRACT
BACKGROUND:
The relationship between tumor necrosis factor (TNF)-related parameters and cardiorenal metabolic factors is still controversial in clinical hypertension.METHODS:
Normotensive men (NT, n=60) and treated stage 2 and 3 essential hypertensive men (HT, n=89) were enrolled in this study. The relationship between TNF-related parameters and cardiorenal metabolic factors was examined in NT and HT, separately.RESULTS:
HT showed higher rates of insulin resistance and enhanced chronic inflammation compared with NT. The levels of soluble TNF receptor 1 and 2 were significantly higher in HT than in NT, although TNF-α levels were unexpectedly lower in HT than in NT. Regression analysis indicated that the TNF-related parameters were closely linked with mild renal dysfunction both in NT and HT, and moderately related to chronic inflammation only in HT. HT taking inhibitors of the renin-angiotensin system showed improved insulin resistance, but no difference in the TNF-related parameters.CONCLUSION:
These results suggest that the disturbed TNF system is closely linked with chronic inflammation rather than with insulin resistance in HT.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Insulin Resistance
/
Tumor Necrosis Factor-alpha
/
Hypertension
/
Inflammation
Limits:
Aged
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Int J Biol Markers
Journal subject:
BIOQUIMICA
/
NEOPLASIAS
Year:
2014
Document type:
Article