A 129-kb deletion on chromosome 12 confers substantial protection against rheumatoid arthritis, implicating the gene SLC2A3.

Veal, Colin D; Reekie, Katherine E; Lorentzen, Johnny C; Gregersen, Peter K; Padyukov, Leonid; Brookes, Anthony J

Veal, Colin D; Reekie, Katherine E; Lorentzen, Johnny C; Gregersen, Peter K; Padyukov, Leonid; Brookes, Anthony J.

Affiliation

Veal CD; Department of Genetics, University of Leicester, Leicester, UK.

Hum Mutat ; 35(2): 248-56, 2014 Feb.

Article in En | MEDLINE | ID: mdl-24178905

Subject(s)

Arthritis, Rheumatoid/genetics; Chromosome Deletion; Chromosomes, Human, Pair 12/genetics; DNA Copy Number Variations; Glucose Transporter Type 3/genetics; Alleles; Arthritis, Rheumatoid/metabolism; Chondrocytes/metabolism; Chondrocytes/pathology; Comparative Genomic Hybridization; Genotype; Glucose Transport Proteins, Facilitative/genetics; Homeodomain Proteins/genetics; Homologous Recombination; Humans; Quantitative Trait Loci; Reproducibility of Results; Transcription Factors/genetics

Key words

CNV; GLUT3; SLC2A3; association; rheumatoid arthritis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Rheumatoid / Chromosomes, Human, Pair 12 / Chromosome Deletion / Glucose Transporter Type 3 / DNA Copy Number Variations Limits: Humans Language: En Journal: Hum Mutat Journal subject: GENETICA MEDICA Year: 2014 Document type: Article Affiliation country: United kingdom Country of publication: United States

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