Evaluation of the respiratory elimination kinetics of selenate and Se-methylselenocysteine after oral administration in lambs.
Res Vet Sci
; 95(3): 1163-8, 2013 Dec.
Article
in En
| MEDLINE
| ID: mdl-24210249
ABSTRACT
Sheep can be acutely poisoned by selenium (Se) accumulating forages which often contain selenate or Se-methylselenocysteine as their predominant forms. Excess Se can be eliminated via respiration. Sheep were given a single oral dose of 0, 1, 2, 3, 4, or 6 mg Se/kg BW as sodium selenate and Se-methylselenocysteine or 6 mg Se/kg BW as sodium selenite or selenomethionine. Expired air samples were collected and analyzed for Se. The Se concentration of the expired air reflected a dose-dependent increase at individual time points for both Se-methylselenocysteine and sodium selenate, however, Se content was greater and eliminated more rapidly from sheep receiving Se-methylselenocysteine. The mean Se concentration in respired air from sheep administered 6 mg Se/kg BW of different selenocompounds was greatest in sheep dosed Se-methylselenocysteine > selenomethionine > sodium selenate > sodium selenite. The Se concentration in respired air of acutely poisoned sheep is significantly different for different chemical forms of Se.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Selenocysteine
/
Selenic Acid
Limits:
Animals
Language:
En
Journal:
Res Vet Sci
Year:
2013
Document type:
Article