Analysis of chlorthalidone polymorphs in raw materials and tablets and the effect of forms I and II on the dissolution properties of drug products.

Bonfilio, Rudy; Leal, Jockastta S; Santos, Olímpia M M; Pereira, Gislaine R; Doriguetto, Antônio C; de Araújo, Magali B

Bonfilio, Rudy; Leal, Jockastta S; Santos, Olímpia M M; Pereira, Gislaine R; Doriguetto, Antônio C; de Araújo, Magali B.

Affiliation

Bonfilio R; Faculdade de Ciências Farmacêuticas, Universidade Federal de Alfenas (UNIFAL-MG), CEP 37130-000, Alfenas, MG, Brazil; Instituto de Ciências da Saúde, Universidade Federal de Mato Grosso (UFMT), CEP 78557-267, Campus Universitário de Sinop, Sinop, MT, Brazil. Electronic address: rudybonfilio@yahoo.com.br.

J Pharm Biomed Anal ; 88: 562-70, 2014 Jan.

Article in En | MEDLINE | ID: mdl-24216278

Subject(s)

Antihypertensive Agents/chemistry; Chlorthalidone/chemistry; Drug Compounding; Antihypertensive Agents/analysis; Chemistry, Pharmaceutical; Chlorthalidone/analysis; Chromatography, High Pressure Liquid; Powders; Quality Control; Reference Standards; Solubility; Solvents; Spectrophotometry, Infrared; Tablets; X-Ray Diffraction

Key words

Attenued total reflection infrared spectroscopy; Chlorthalidone; Dissolution studies; Polymorphs; Powder X-ray diffraction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chlorthalidone / Drug Compounding / Antihypertensive Agents Language: En Journal: J Pharm Biomed Anal Year: 2014 Document type: Article

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