FasL on human nucleus pulposus cells prevents angiogenesis in the disc by inducing Fas-mediated apoptosis of vascular endothelial cells.

Sun, Zhen; Wan, Zhong-Yuan; Guo, Yun-Shan; Wang, Hai-Qiang; Luo, Zhuo-Jing

Sun, Zhen; Wan, Zhong-Yuan; Guo, Yun-Shan; Wang, Hai-Qiang; Luo, Zhuo-Jing.

Affiliation

Sun Z; Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University Xi'an, China.

Int J Clin Exp Pathol ; 6(11): 2376-85, 2013.

Article in En | MEDLINE | ID: mdl-24228099

Subject(s)

Apoptosis; Endothelial Cells/metabolism; Fas Ligand Protein/metabolism; Intervertebral Disc Degeneration/metabolism; Intervertebral Disc/metabolism; Neovascularization, Pathologic; fas Receptor/metabolism; Adult; Caspase 3/metabolism; Cells, Cultured; Coculture Techniques; Endothelial Cells/pathology; Fas-Associated Death Domain Protein/metabolism; Female; Humans; Intervertebral Disc/pathology; Intervertebral Disc Degeneration/pathology; Male; Middle Aged; Paracrine Communication; Signal Transduction

Key words

Fas; FasL; HMEC-1; Intervertebral disc; nucleus pulposus; vascular endothelial cells

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Apoptosis / Fas Receptor / Endothelial Cells / Fas Ligand Protein / Intervertebral Disc Degeneration / Intervertebral Disc / Neovascularization, Pathologic Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Int J Clin Exp Pathol Journal subject: PATOLOGIA Year: 2013 Document type: Article Affiliation country: China Country of publication: United States

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