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Radiofrequency ablation of thoracic tumours: lessons learned with ablation of 100 lesions.
Garetto, Irene; Busso, Marco; Sardo, Diego; Filippini, Claudia; Solitro, Federica; Grognardi, Maria Luisa; Veltri, Andrea.
Affiliation
  • Garetto I; Dipartimento di Oncologia, Istituto di Radiologia, Università di Torino, Regione Gonzole 10, 10043, Orbassano, TO, Italy.
Radiol Med ; 119(1): 33-40, 2014 Jan.
Article in En | MEDLINE | ID: mdl-24234185
ABSTRACT

PURPOSE:

Our aim was to analyse the results of our first 100 radiofrequency ablation (RFA) procedures, of primary (nonsmall-cell lung cancers, NSCLC) and secondary (MTS) lung cancers to assess what lessons could be learned from our experience. MATERIALS AND

METHODS:

We analysed 100 lesions (mean size 23 mm) in 81 patients (25 NSCLC/56 MTS). On the basis of the clinical-radiological evolution, we analysed complete ablation (CA) versus partial ablation (PA) at the first computed tomography (CT) scan and during the follow-up (mean 23 months), time to progression (TTP) and survival. Possible predictive factors for local effectiveness and survival were sought.

RESULTS:

At the first CT scan CA was obtained in 88 %; the difference between the mean diameter of lesions achieving CA and PA was significant (20 versus 38 mm; p = 0.0001). A threshold of 30 mm (p = 0.0030) and the histological type (NSCLC 75 %/MTS 94 %; p = 0.0305) were also predictive of CA. A total of 18.4 % of the CA recurred (average TTP 19 months). Survival at 1, 2 and 3 years was 84.5, 65.4 and 51.5 %, respectively. The predictors of survival at 3 years were the coexistence of other MTS (p = 0.0422) and a diameter <20 mm (p = 0.0323), but not the local effectiveness of RFA.

CONCLUSION:

RFA for thoracic malignancies is accurate for lesions up to 30 mm, especially if metastatic; survival is more closely related to staging factors than to the local effectiveness of RFA.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Postoperative Complications / Tomography, X-Ray Computed / Catheter Ablation / Carcinoma, Non-Small-Cell Lung / Lung Neoplasms Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Radiol Med Year: 2014 Document type: Article Affiliation country: Italy

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Postoperative Complications / Tomography, X-Ray Computed / Catheter Ablation / Carcinoma, Non-Small-Cell Lung / Lung Neoplasms Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Radiol Med Year: 2014 Document type: Article Affiliation country: Italy