Effect of atorvastatin on renal NO availability and tubular function in patients with stage II-III chronic kidney disease and type 2 diabetes.
Scand J Clin Lab Invest
; 74(1): 8-19, 2014 Jan.
Article
in En
| MEDLINE
| ID: mdl-24256611
ABSTRACT
BACKGROUND:
Statins have beneficial effects on cardiovascular morbidity and mortality independently of reduction of plasma cholesterol. PURPOSE ANDMETHODS:
In patients with type 2 diabetes and nephropathy, chronic kidney disease stage II-III, we tested the hypothesis that atorvastatin increased systemic and renal nitric oxide (NO) availability using L-NMMA as an inhibitor of NO production. We performed a randomized, placebo-controlled, crossover study, using atorvastatin/placebo treatment for five days with a standardized diet and fluid intake. We measured brachial BP (bBP), central BP (cBP), GFR, urinary output (OU), free water clearance (CH2O), fractional excretion of sodium (FENa), urinary excretion of albumin (UAER and UACR), AQP2 (u-AQP2) and ENaC (u-ENaCγ) and plasma concentrations of vasoactive hormones renin, angiotensin II, aldosterone, arginine vasopressin, endothelin-1 and brain natriuretic peptide.RESULTS:
During atorvastatin and placebo treatment, L-NMMA infusion, changed the effect variables significantly, but to the same extent, i.e. an increase in bBP and cBP, and a decrease in GFR, OU, CH2O, FENa, u-AQP2 and u-ENaCγ. In addition, renin and angiotensin II was reduced, aldosterone increased, and vasopressin, endothelin-1 and brain natriuretic hormone unchanged.CONCLUSION:
During, atorvastatin and placebo treatment, inhibition of nitric oxide synthesis induced the same response in brachial and central blood pressure, GFR, renal tubular function and vasoactive hormones. Thus, atorvastatin did not change nitric oxide availability in type 2 diabetics with nephropathy.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyrroles
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Hydroxymethylglutaryl-CoA Reductase Inhibitors
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Diabetes Mellitus, Type 2
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Renal Insufficiency, Chronic
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Heptanoic Acids
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Kidney Tubules
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Nitric Oxide
Type of study:
Clinical_trials
Limits:
Aged
/
Female
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Humans
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Male
/
Middle aged
Language:
En
Journal:
Scand J Clin Lab Invest
Year:
2014
Document type:
Article