ß-arrestin promotes Wnt-induced low density lipoprotein receptor-related protein 6 (Lrp6) phosphorylation via increased membrane recruitment of Amer1 protein.

Kríz, Vítezslav; Pospíchalová, Vendula; Masek, Jan; Kilander, Michaela Brita Christina; Slavík, Josef; Tanneberger, Kristina; Schulte, Gunnar; Machala, Miroslav; Kozubík, Alois; Behrens, Juergen; Bryja, Vítezslav

Kríz, Vítezslav; Pospíchalová, Vendula; Masek, Jan; Kilander, Michaela Brita Christina; Slavík, Josef; Tanneberger, Kristina; Schulte, Gunnar; Machala, Miroslav; Kozubík, Alois; Behrens, Juergen; Bryja, Vítezslav.

Affiliation

Kríz V; From the Faculty of Science, Institute of Experimental Biology, Masaryk University, 611 37 Brno, Czech Republic.

J Biol Chem ; 289(2): 1128-41, 2014 Jan 10.

Article in En | MEDLINE | ID: mdl-24265322

Subject(s)

Adaptor Proteins, Signal Transducing/metabolism; Arrestins/metabolism; Cell Membrane/metabolism; Low Density Lipoprotein Receptor-Related Protein-6/metabolism; Tumor Suppressor Proteins/metabolism; Wnt3A Protein/metabolism; Adaptor Proteins, Signal Transducing/genetics; Animals; Arrestins/genetics; Blotting, Western; Cells, Cultured; Dishevelled Proteins; Embryo, Mammalian/cytology; Fibroblasts/cytology; Fibroblasts/metabolism; HEK293 Cells; Humans; Low Density Lipoprotein Receptor-Related Protein-6/genetics; Mice; Mice, Knockout; Microscopy, Confocal; Minor Histocompatibility Antigens; Phosphatidylinositol 4,5-Diphosphate/metabolism; Phosphoproteins/genetics; Phosphoproteins/metabolism; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor)/genetics; Phosphotransferases (Alcohol Group Acceptor)/metabolism; Protein Binding; RNA Interference; Tumor Suppressor Proteins/genetics; Wnt3A Protein/genetics; beta-Arrestins

Key words

Amer1/WTX/FAM123B; Dvl; Lrp6 Phosphorylation; Membrane Lipids; Phosphatidylinositol Kinase; Phosphatidylinositol Phosphate Kinase; Phosphatidylinositol Signaling; Wnt Signaling; ß-Arrestin; ß-Catenin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Membrane / Arrestins / Tumor Suppressor Proteins / Adaptor Proteins, Signal Transducing / Wnt3A Protein / Low Density Lipoprotein Receptor-Related Protein-6 Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2014 Document type: Article Affiliation country: Czech Republic Country of publication: United States

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