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The BALB/c-specific polymorphic SIRPA enhances its affinity for human CD47, inhibiting phagocytosis against human cells to promote xenogeneic engraftment.
Iwamoto, Chika; Takenaka, Katsuto; Urata, Shingo; Yamauchi, Takuji; Shima, Takahiro; Kuriyama, Takuro; Daitoku, Shinya; Saito, Yasuyuki; Miyamoto, Toshihiro; Iwasaki, Hiromi; Kitabayashi, Issay; Itoh, Katsuhiko; Kishimoto, Junji; Kohda, Daisuke; Matozaki, Takashi; Akashi, Koichi.
Affiliation
  • Iwamoto C; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
  • Takenaka K; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
  • Urata S; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
  • Yamauchi T; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
  • Shima T; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
  • Kuriyama T; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
  • Daitoku S; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
  • Saito Y; Laboratory of Biosignal Sciences, Institute for Molecular and Cellular Regulation, Gunma University, Gunma, Japan.
  • Miyamoto T; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
  • Iwasaki H; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
  • Kitabayashi I; Division of Hematological Malignancy, National Cancer Center Research Institute, Tokyo, Japan.
  • Itoh K; Department of Clinical Molecular Biology, Faculty of Medicine, Kyoto University, Kyoto, Japan.
  • Kishimoto J; Digital Medicine Initiative, Kyushu University, Fukuoka, Japan.
  • Kohda D; Division of Structural Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
  • Matozaki T; Laboratory of Biosignal Sciences, Institute for Molecular and Cellular Regulation, Gunma University, Gunma, Japan; Division of Molecular and Cellular Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan.
  • Akashi K; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan. Electronic address: akashi@med.kyushu-u.ac.jp.
Exp Hematol ; 42(3): 163-171.e1, 2014 Mar.
Article in En | MEDLINE | ID: mdl-24269920
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phagocytosis / Hematopoietic Stem Cells / Receptors, Immunologic / CD47 Antigen / Macrophages Limits: Animals / Humans Language: En Journal: Exp Hematol Year: 2014 Document type: Article Affiliation country: Japan
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phagocytosis / Hematopoietic Stem Cells / Receptors, Immunologic / CD47 Antigen / Macrophages Limits: Animals / Humans Language: En Journal: Exp Hematol Year: 2014 Document type: Article Affiliation country: Japan